PROFESSIONAL ACTIVITY

1991-present: Center for Molecular Design, Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis.
Position: Research Professor for Biomedical Computing. Fields of Interest: Molecular modeling for angiotensin analogs, for LHRH analogs and CCK-8 analogs. Design of opioid peptides, CCK related analogs, angiotensin analogs and LHRH antagonists (in all cases confirmed by synthesis of active analogs). Design of new conformationally directed CCK/opioid peptides. Problems of solution conformations for flexible peptides. Molecular recognition in proteins. Modeling of transmembrane receptor proteins.

1989-1991: Department of Chemistry, University of Arizona, Tucson.
Position: Consultant, Research Associate. Fields of Interest: Development of a model for the delta-receptor-bound conformation of opioid peptides (confirmed by synthesis of cyclic analogs). Molecular modeling for alpha-melanotropins (confirmed by synthesis of cyclic analogs with different activities). Development of CCK-8 receptor-bound conformations for A- and B-types of receptors.

1977-1989: Institute of Organic Synthesis, Latvian Ac. Sci., Riga, U.S.S.R.
Position: Head of Research Group. Fields of interest: Energy calculations for several peptides including angiotensin, tetragastrin, oxytocin and vasopressin, tuftsin, alpha-melanotropin, substance P, neurotensin, xenopsin, enkephalines. Development of an approach for determination of biologically active conformations for oligopeptides based on energy calculations. Molecular modeling for angiotensin, bradykinin, tuftsin, alpha-melanotropin and other series based on a quasicyclization hypothesis (confirmed by synthesis of cyclic analogues both in the U.S.S.R. and in the U.S.A.). Development of an approach to determination of peptide conformation in solution based on combining the experimental and calculated data on structural parameters. Publications: Three monographs in Russian and more than 100 papers and abstracts both in Russian and in English; those in Russian mostly are indexed in Chemical Abstracts, Current Contents and on Web of Science.

1968–1977: Institute of Heat and Mass Transfer, Belorussian Ac. Sci., Minsk, U.S.S.R.
Position: Research Scientist. Fields of interest: Methods of energy calculations for peptide molecules and other polymers. Diffusion of inert gases in crystal polymers. Parameters for description of atom-atom interactions. Energy calculations for amino acid dipeptide units and for few oligopeptides, including bradykinin. Publications: Two monographs and more than 45 papers and abstracts in Russian; some of them are indexed in Chemical Abstracts, Current Contents and on Web of Science.