COLLABORATIONS
Dr. Thomas J. Baranski(2005 – present)
Department of Medicine
Washington University
St. Louis, MO 63110, U.S.A.
Studies of 3D Structure of G-protein coupled receptors, specifically of C5a receptor
Publications:
Hagemann, I. S., Nikiforovich, G. V., and Baranski, T. J. (2006) Comparison of the retinitis pigmentosa mutations in rhodopsin with a functional map of the C5a receptor, Vision Research 46, 4519-31 [PDF].
Klco, J. M., Nikiforovich, G. V., and Baranski, T. J. (2006) Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop, Journal of Biological Chemistry 281, 12010-9 [PDF].
Matsumoto, M. L., Narzinski, K., Kiser, P. D., Nikiforovich, G. V., and Baranski, T. J. (2007) A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues, Journal of Biological Chemistry 282, 3105-21 [PDF].
Matsumoto, M. L., Narzinski, K., Nikiforovich, G. V., and Baranski, T. J. (2007) A comprehensive structure-function map of the intracellular surface of the human C5a receptor. II. Elucidation of G protein specificity determinants, Journal of Biological Chemistry 282, 3122-33 [PDF].
Dr. Samuel Achilefu(2003 – present)
Department of Radiology
Washington University
St. Louis, MO 63110, U.S.A.
Design of targeted peptide compounds with optical labels
Publications:
Ye, Y., Li, W., Anderson, C. J., Kao, J., Nikiforovich, G. V., and Achilefu, S. (2003) Synthesis and Characterization of a Macrocyclic Near Infrared Optical Scaffold, J. Am. Chem. Soc. 125, 7766-7767 [PDF].
Bloch, S., Xu, B., Ye, Y., Liang, K., Nikiforovich, G. V., and Achilefu, S. (2006) Targeting Beta-3 integrin using a linear hexapeptide labeled with a near-infrared fluorescent molecular probe, Molecular Pharmaceutics 3, 539-49 [PDF].
Berezin, M. Y., Lee, H., Akers, W., Nikiforovich, G. V., and Achilefu, S. (2007) Ratiometric Analysis of Fluorescence Lifetime for Probing Binding Sites in Albumin with Near-Infrared Fluorescent Molecular Probes, Photochemistry and Photobiology 83, 1371-1378 [PDF].
Dr. Anders Hallberg, Dr. Anders Karlén(2000 – present)
Department of Organic Pharmaceutical Chemistry
Biomedical Centre
Uppsala University
P.O. Box 574, S-751, 23 Uppsala, Sweden
Studies of molecular interaction mechanism of ligands with angiotensin receptors
Publications:
Johanesson, P., Lindeberg, G., Johanson, A., Nikiforovich, G. V., Gogoll, A., Synnergren, B., Le Greves, M., Nyberg, F., Karlen, A., and Hallberg, A. (2002) Vinyl Sulfide Cyclized Analogues of Angiotensin II with High Affinity and Full Agonist Activity at the AT1 Receptor, J. Med. Chem. 45, 1767-1777 [PDF]
Sköld, C., Nikiforovich, G. V., and Karlen, A. (2008) Model of the Angiotensin II type-2 Receptor for Exploring the Binding Mode of Angiotensin II and Pseudopeptide Analogues, Journal of Molecular Graphics and Modelling 26, 991-1003 [PDF].
Dr. Niels H. Andersen(2000 – 2003)
Department of Chemistry
University of Washington
Seattle, WA 98195, U.S.A
Studies of folding pathways for mini-proteins.
Publications:
Nikiforovich GV, Andersen NH, Fesinmeyer RM, Frieden C. Possible Locally Driven Folding Pathways of TC5b, A 20-Residue Protein. Proteins: Structure, Function, and Genetics 2003:52, 292-302 [PDF].
Dr.
Carl Frieden(2000 – 2003)
Department of Biochemistry and Molecular Biophysics
Washington University
St. Louis, MO 63110, U.S.A.
Studies of local structure in denatured state of proteins.
Publications:
Nikiforovich GV, Frieden C. The search for local native-like nucleation centers in the unfolded state of Beta-sheet proteins. Proc. Natl. Acad. Sci. USA 2002;99(16):10388-10393 [PDF].
Nikiforovich GV Elements of non-random structure in the unfolded states of proteins: Location and possible implications for protein folding mechanisms, Polimery 2003; 48, 44-49.
Dr. Katalin E. Kövèr(1996 – 2002)
Department of Chemistry
University of Debrecen
H-4010, Debrecen, Hungary
Publications:
Shenderovich MD, Kover KE, Nikiforovich GV, Jiao D, Hruby VJ. Conformational Analysis of Beta-Methylphenylalanine Stereoisomers of DPDPE using NMR Data and Conformational Energy Calculations. Biopolymers 1996; 38(2):141-156. [PDF]
Nikiforovich GV, Kövér KE, Kolodziej SA, et al. Design and Comprehensive Conformational Studies of DPMPT and DPDMPT: Novel Conformationally Constrained Opioid Peptides. J. Am. Chem. Soc. 1996; 118: 959-969. [PDF]
Nikiforovich GV, Kövér KE, Zhang WJ, Marshall GR. Cyclopentapeptides as Flexible Conformational Templates. J. Am. Chem. Soc. 2000;122(14):3262-3273. [PDF]
Dr.
Manfred Mutter, Dr. Christian Lehmann(1998 – 1999)
University of Lausanne
BCH-Dorigny, CH-1015 Lausanne, Switzerland
Molecular modeling and design of specific cyclopeptide templates.
Publications:
Nikiforovich GV, Mutter M, Lehmann C. Molecular modeling and design of regioselectively addressable functionalized templates (RAFT) with rigidified 3D structures. Biopolymers 1999; 50(4):361-372. [PDF].
Dr.
Isabella Karle, Dr. Judith Flippen-Anderson(1996 - 1997)
Naval Research Laboratory, Washington, DC
Molecular modeling and design of delta-opioid peptides.
Publications:
Flippen-Anderson JL, Deschamps JR, George C, Nikiforovich GV, et al. X-ray Structure of Tyr-D-Tic-Phe-Phe-NH2 (D-TIPP-NH2), a Highly Potent mu-Receptor Selective Opioid Agonist: Comparisons with Proposed Model Structures. J. Peptide Res. 1997; 49; 384-393.